You can click on the question mark in every page to get an interactive tutorial. If you start the tutorial from the search page you can have a full overview of Polympact.
- additive: models computed with a class for each possible genotype combination (Reference Homozygous, Heterozygous, Alternative Homozygous)
- dominant: models computed with two classes for genotype combinations (Reference Homozygous, Heterozygous + Alternative Homozygous)
- recessive: models computed with two classes for genotype combinations (Reference Homozygous, + Heterozygous, Alternative Homozygous)
- match: Select motifs where the score with reference allele and the score with alternative allele differs less than 10%
- change: Select motifs where the score with reference allele and the score with alternative allele differs more than 10%
- addition: Select motifs where the score with alternative allele is greater than 0 while the score with reference allele is less than 0
- deletion: Select motifs where the score with reference allele is greater than 0 while the score with alternative allele is less than 0
Polympact is based on human reference genome hg19
Quick search uses the default parameters while advanced search allows the tuning of the parameters
The data are available at this link
If you use Polympact please cite:
Samuel Valentini, Francesco Gandolfi, Mattia Carolo, Davide Dalfovo, Lara Pozza, Alessandro Romanel
Polympact: exploring functional relations among common human genetic variants
Nucleic Acids Research, 2022; DOI:https://doi.org/10.1093/nar/gkac024, PMID: 35061909