Polympact Help



FAQ'S

Where can I get help on the usage of the interface?

You can click on the question mark in every page to get an interactive tutorial. If you start the tutorial from the search page you can have a full overview of Polympact.


What are the models in the linear model associations?

- additive: models computed with a class for each possible genotype combination (Reference Homozygous, Heterozygous, Alternative Homozygous)
 
- dominant: models computed with two classes for genotype combinations (Reference Homozygous, Heterozygous + Alternative Homozygous)
 
- recessive: models computed with two classes for genotype combinations (Reference Homozygous, + Heterozygous, Alternative Homozygous)
 


What are the binding model effects?

- match: Select motifs where the score with reference allele and the score with alternative allele differs less than 10%
 
- change: Select motifs where the score with reference allele and the score with alternative allele differs more than 10%
 
- addition: Select motifs where the score with alternative allele is greater than 0 while the score with reference allele is less than 0
 
- deletion: Select motifs where the score with reference allele is greater than 0 while the score with alternative allele is less than 0
 


Which version of the human reference genome is Polympact based on?

Polympact is based on human reference genome hg19


What is the difference between quick and advanced search?

Quick search uses the default parameters while advanced search allows the tuning of the parameters


Where can I find the Polympact examples data?

The data are available at this link


How can I cite Polympact?

If you use Polympact please cite:
Samuel Valentini, Francesco Gandolfi, Mattia Carolo, Davide Dalfovo, Lara Pozza, Alessandro Romanel
Polympact: exploring functional relations among common human genetic variants
Nucleic Acids Research, 2022; DOI:https://doi.org/10.1093/nar/gkac024, PMID: 35061909